CDC reports most J&J vaccine side effects are 'nonserious,' 17 cases of blood clot condition

A new review of Johnson & Johnson Covid-19 vaccine safety moni...

Posted: Apr 30, 2021 5:01 PM
Updated: Apr 30, 2021 5:02 PM

A new review of Johnson & Johnson Covid-19 vaccine safety monitoring data finds that only 3% of reported reactions after receiving the vaccine are classified as serious -- and there have been a total of 17 incidents of severe blood clotting while also experiencing low blood platelet levels.

The report, published on Friday by the US Centers for Disease Control and Prevention, notes that the safety profile of the vaccine so far has been similar to what was seen in clinical trials, but safety monitoring during the vaccine's rollout quickly identified the blood clot incidents.

"A rare but serious adverse event occurring primarily in women, blood clots in large vessels accompanied by a low platelet count, was rapidly detected by the U.S. vaccine safety monitoring system," CDC researchers wrote in the report. "Monitoring for common and rare adverse events after receipt of all COVID-19 vaccines, including the Janssen COVID-19 vaccine, is continuing."

Janssen is the vaccine arm of Johnson & Johnson. In February, the Johnson & Johnson vaccine was authorized for emergency use in the United States. Use of the vaccine was paused temporarily in mid-April due to reports of extremely rare yet severe blood clotting events in the brain's venous sinuses following vaccinations. The pause lifted last week.

The new CDC report summarizes the latest safety data on the vaccine, which includes 13,725 incidents reported through the agency's Vaccine Adverse Events Reporting System. The data showed that 97% of the events have been nonserious.

Overall, there were 17 events consistent with what has been described as thrombosis with thrombocytopenia syndrome, or blood clotting with low blood platelet levels -- including 14 that were cerebral venous sinus thrombosis and three that did not involve the brain's venous sinuses among women younger than 60 during the vaccine pause, according to the report.

The data also included 88 deaths reported after vaccination. Among those deaths, three occurred in patients with cerebral venous sinus thrombosis and CDC researchers wrote that, after preliminary reviews, "no other deaths appear to have an association with vaccination."

Increased number of 'anxiety-related events'

Additional new data published Friday from the CDC suggests that administration of Johnson & Johnson's Covid-19 vaccine in early April may have also been connected to an increased incidence of "anxiety-related events" in the 15-minute waiting period post-vaccine.

All of these anxiety-related events occurred before reports came out of thrombosis with thrombocytopenia syndrome connected to the Janssen vaccine.

In a study published Friday in the CDC's Morbidity and Mortality Weekly Report, researchers examined data from five mass vaccination sites which reported increased anxiety-related events, including rapid heart rate, rapid breathing, and fainting, following administration of Johnson & Johnson's Janssen Covid-19 vaccine from April 7-9.

Researchers tallied 64 anxiety-related events out of 8,624 vaccine recipients. The rate of syncope, or fainting, was found to be 8.2 incidences per 100,000 doses, which is 164 times the rate of fainting following the flu vaccine, the researchers wrote.

All of the events were reported to Vaccine Adverse Event Reporting System, and none were considered "serious" by VAERS standards. Over half of the reported fainting events occurred in women. For four out of the five sites observed, these events happened on the first day of Janssen shot administration.

Study authors suggested that because the Janssen Covid-19 vaccine is a single-dose shot, people with a fear of needles may be more inclined to get this shot over one of the two-dose options. Out of all fainting cases, 20% of those reported occurred in people who had already informed vaccination site staff they had a history of needle aversion.

Half of the reports of fainting occurred in people ages 18 to 29, and fainting associated with injections is more common in adolescents and young adults. Researchers cited similar fainting rates in administration of the human papillomavirus vaccine, largely given to young people. The HPV vaccine has a fainting rate of 7.8 per 100,000.

Researchers said tracking anxiety event rates will be important information for health care providers as the Covid-19 vaccine reaches more and more young people.

"Anxiety-related events can occur after any vaccination," study authors wrote.

"It is important that vaccination providers are aware that anxiety-related adverse events might be reported more frequently after receipt of the Janssen COVID-19 vaccine than after influenza vaccination and observe all COVID-19 vaccine recipients for any adverse reactions for at least 15 minutes after vaccine administration," the researchers wrote. "As use of COVID-19 vaccines expands into younger age groups, providers should be aware that younger persons might be more highly predisposed to anxiety-related events after vaccination than are older persons."

Mississippi Coronavirus Cases

Data is updated nightly.

Cases: 314710

Reported Deaths: 7254
CountyCasesDeaths
DeSoto21646260
Hinds20369416
Harrison17949309
Rankin13643278
Jackson13450246
Madison10113217
Lee9986174
Jones8384163
Forrest7689152
Lauderdale7198240
Lowndes6403148
Lamar623686
Lafayette6203119
Washington5341134
Bolivar4802132
Oktibbeha462998
Panola4596107
Pearl River4519146
Marshall4450103
Warren4393121
Pontotoc420872
Monroe4115133
Union411176
Neshoba4031176
Lincoln3969110
Hancock379586
Leflore3498125
Sunflower336290
Tate334784
Pike3327105
Scott316274
Alcorn313368
Yazoo311770
Itawamba300577
Copiah297465
Coahoma295579
Simpson295388
Tippah288768
Adams286982
Prentiss280060
Marion269380
Leake268473
Wayne262841
Grenada261587
Covington259881
George248148
Newton246862
Winston227581
Tishomingo227067
Jasper221148
Attala214473
Chickasaw208057
Holmes189174
Clay185554
Stone182833
Tallahatchie178941
Clarke178080
Calhoun170932
Yalobusha164638
Smith162534
Walthall134245
Greene130633
Lawrence128724
Montgomery127142
Noxubee126734
Perry126338
Amite123142
Carroll121829
Webster114532
Jefferson Davis107133
Tunica105726
Claiborne102430
Benton100025
Humphreys96733
Kemper95828
Franklin83923
Quitman81116
Choctaw76418
Wilkinson67531
Jefferson65728
Sharkey50217
Issaquena1686
Unassigned00

Alabama Coronavirus Cases

Cases: 537813

Reported Deaths: 11024
CountyCasesDeaths
Jefferson791691529
Mobile41177808
Madison35002507
Tuscaloosa25871454
Shelby25076249
Montgomery24549591
Baldwin21290309
Lee15946171
Calhoun14556319
Morgan14364280
Etowah13890353
Marshall12262223
Houston10602282
Elmore10115206
Limestone10031151
St. Clair9890245
Cullman9730194
Lauderdale9449243
DeKalb8853188
Talladega8325176
Walker7259277
Autauga6971108
Jackson6830112
Blount6750139
Colbert6317134
Coffee5546119
Dale4869113
Russell444338
Chilton4343113
Franklin426282
Covington4138118
Tallapoosa4040152
Escambia394577
Chambers3581123
Dallas3564153
Clarke351361
Marion3137101
Pike311977
Lawrence302298
Winston275673
Bibb263064
Geneva252577
Marengo249664
Pickens234862
Barbour231956
Hale223677
Butler217869
Fayette212462
Henry189644
Cherokee184345
Randolph182042
Monroe178140
Washington167639
Macon160750
Clay156957
Crenshaw153357
Cleburne149241
Lamar143035
Lowndes139653
Wilcox127430
Bullock123041
Conecuh110629
Coosa108928
Perry107826
Sumter104932
Greene92634
Choctaw61024
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