CDC reports most J&J vaccine side effects are 'nonserious,' 17 cases of blood clot condition

A new review of Johnson & Johnson Covid-19 vaccine safety moni...

Posted: Apr 30, 2021 5:01 PM
Updated: Apr 30, 2021 5:02 PM

A new review of Johnson & Johnson Covid-19 vaccine safety monitoring data finds that only 3% of reported reactions after receiving the vaccine are classified as serious -- and there have been a total of 17 incidents of severe blood clotting while also experiencing low blood platelet levels.

The report, published on Friday by the US Centers for Disease Control and Prevention, notes that the safety profile of the vaccine so far has been similar to what was seen in clinical trials, but safety monitoring during the vaccine's rollout quickly identified the blood clot incidents.

"A rare but serious adverse event occurring primarily in women, blood clots in large vessels accompanied by a low platelet count, was rapidly detected by the U.S. vaccine safety monitoring system," CDC researchers wrote in the report. "Monitoring for common and rare adverse events after receipt of all COVID-19 vaccines, including the Janssen COVID-19 vaccine, is continuing."

Janssen is the vaccine arm of Johnson & Johnson. In February, the Johnson & Johnson vaccine was authorized for emergency use in the United States. Use of the vaccine was paused temporarily in mid-April due to reports of extremely rare yet severe blood clotting events in the brain's venous sinuses following vaccinations. The pause lifted last week.

The new CDC report summarizes the latest safety data on the vaccine, which includes 13,725 incidents reported through the agency's Vaccine Adverse Events Reporting System. The data showed that 97% of the events have been nonserious.

Overall, there were 17 events consistent with what has been described as thrombosis with thrombocytopenia syndrome, or blood clotting with low blood platelet levels -- including 14 that were cerebral venous sinus thrombosis and three that did not involve the brain's venous sinuses among women younger than 60 during the vaccine pause, according to the report.

The data also included 88 deaths reported after vaccination. Among those deaths, three occurred in patients with cerebral venous sinus thrombosis and CDC researchers wrote that, after preliminary reviews, "no other deaths appear to have an association with vaccination."

Increased number of 'anxiety-related events'

Additional new data published Friday from the CDC suggests that administration of Johnson & Johnson's Covid-19 vaccine in early April may have also been connected to an increased incidence of "anxiety-related events" in the 15-minute waiting period post-vaccine.

All of these anxiety-related events occurred before reports came out of thrombosis with thrombocytopenia syndrome connected to the Janssen vaccine.

In a study published Friday in the CDC's Morbidity and Mortality Weekly Report, researchers examined data from five mass vaccination sites which reported increased anxiety-related events, including rapid heart rate, rapid breathing, and fainting, following administration of Johnson & Johnson's Janssen Covid-19 vaccine from April 7-9.

Researchers tallied 64 anxiety-related events out of 8,624 vaccine recipients. The rate of syncope, or fainting, was found to be 8.2 incidences per 100,000 doses, which is 164 times the rate of fainting following the flu vaccine, the researchers wrote.

All of the events were reported to Vaccine Adverse Event Reporting System, and none were considered "serious" by VAERS standards. Over half of the reported fainting events occurred in women. For four out of the five sites observed, these events happened on the first day of Janssen shot administration.

Study authors suggested that because the Janssen Covid-19 vaccine is a single-dose shot, people with a fear of needles may be more inclined to get this shot over one of the two-dose options. Out of all fainting cases, 20% of those reported occurred in people who had already informed vaccination site staff they had a history of needle aversion.

Half of the reports of fainting occurred in people ages 18 to 29, and fainting associated with injections is more common in adolescents and young adults. Researchers cited similar fainting rates in administration of the human papillomavirus vaccine, largely given to young people. The HPV vaccine has a fainting rate of 7.8 per 100,000.

Researchers said tracking anxiety event rates will be important information for health care providers as the Covid-19 vaccine reaches more and more young people.

"Anxiety-related events can occur after any vaccination," study authors wrote.

"It is important that vaccination providers are aware that anxiety-related adverse events might be reported more frequently after receipt of the Janssen COVID-19 vaccine than after influenza vaccination and observe all COVID-19 vaccine recipients for any adverse reactions for at least 15 minutes after vaccine administration," the researchers wrote. "As use of COVID-19 vaccines expands into younger age groups, providers should be aware that younger persons might be more highly predisposed to anxiety-related events after vaccination than are older persons."

Mississippi Coronavirus Cases

Data is updated nightly.

Cases: 468498

Reported Deaths: 9100
CountyCasesDeaths
Harrison31907468
Hinds30552569
DeSoto29532342
Jackson22868335
Rankin21016355
Lee14393214
Madison13961263
Jones13053215
Forrest12879231
Lauderdale11244292
Lowndes10148171
Lamar9972122
Pearl River8569208
Lafayette8008136
Hancock7110107
Oktibbeha6764117
Washington6756146
Neshoba6350200
Monroe6304156
Warren6267159
Panola6036122
Pontotoc599292
Bolivar5960143
Marshall5917115
Union558885
Pike5424133
Lincoln5192127
Alcorn509388
George454766
Scott447392
Leflore4377138
Tippah431780
Itawamba429192
Prentiss429074
Copiah423883
Simpson4238108
Wayne419663
Tate418999
Adams4174109
Yazoo411486
Sunflower4057104
Covington404891
Marion399699
Leake389784
Coahoma385996
Newton360273
Grenada3489100
Stone342657
Tishomingo320987
Attala318285
Jasper308261
Winston298191
Clay282672
Chickasaw277464
Clarke271784
Holmes257685
Calhoun256939
Smith241546
Yalobusha215447
Tallahatchie213849
Walthall203457
Lawrence202431
Greene202045
Perry195053
Amite191251
Webster191141
Noxubee173437
Montgomery168652
Jefferson Davis164041
Carroll158936
Tunica146533
Benton137531
Kemper136538
Claiborne124134
Choctaw123824
Humphreys122036
Franklin114127
Quitman100925
Wilkinson98335
Jefferson85832
Sharkey61620
Issaquena1916
Unassigned00

Alabama Coronavirus Cases

Cases: 757893

Reported Deaths: 12784
CountyCasesDeaths
Jefferson1082301712
Mobile694251158
Madison47738562
Baldwin35347420
Shelby34758281
Tuscaloosa32576495
Montgomery32249645
Lee21576200
Calhoun19621363
Morgan19061307
Etowah18363413
Marshall17028252
Houston15881337
St. Clair14724270
Limestone13908178
Elmore13812239
Cullman13756228
Lauderdale12909263
Talladega12124200
DeKalb11705220
Walker10047303
Autauga9371119
Blount9272146
Jackson8970132
Coffee8550150
Colbert8229160
Dale8162142
Escambia632298
Tallapoosa6255165
Covington6214153
Chilton6152128
Russell586753
Franklin558292
Chambers5155127
Dallas4569173
Marion4490114
Clarke447070
Pike439188
Geneva415999
Lawrence4002101
Winston399982
Bibb388975
Barbour334667
Marengo317778
Monroe306844
Butler305878
Pickens296166
Henry288550
Randolph288255
Hale282981
Cherokee275649
Fayette268569
Washington241844
Crenshaw226962
Clay219260
Macon211154
Cleburne205746
Lamar184638
Conecuh173337
Lowndes167856
Coosa160031
Wilcox153033
Bullock145642
Perry132430
Sumter122635
Greene117941
Choctaw71925
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