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CDC study finds Pfizer, Moderna vaccines are 90% effective after two doses in real-world conditions

Under real world conditions, the Pfizer and Moderna Covid-19 vaccines provide highly effective protection, according to a new report from the...

Posted: Mar 29, 2021 4:12 PM
Updated: Mar 29, 2021 11:15 PM

Under real world conditions, the Pfizer and Moderna Covid-19 vaccines provide highly effective protection, according to a new report from the US Centers for Disease Control and Prevention.

At full vaccination, the vaccines were 90% effective at preventing infections, including infections that had no symptoms. At least 14 days after first dose but before second dose, they were 80% protective, according to the agency's Morbidity and Mortality Weekly Report published Monday. The CDC said it is the first of many planned Covid-19 vaccine effectiveness studies.

The study looked at how the vaccines protected nearly 4,000 health care workers and first responders. The volunteers in the study worked in eight locations around the country and had been observed from mid-December to mid-March.

The CDC tested volunteers routinely regardless of symptoms. The CDC also monitored the volunteers through text message, e-mail and direct medical reports. The volunteers also did a nasal swab once a week.

Most of the volunteers, more than 62%, had received both doses of either a Pfizer or Moderna Covid-19 vaccine. More than 12% had received just a single dose.

Among the 2,961 people vaccinated with one or more doses and the 989 unvaccinated participants, a total of 205 had a positive PCR test for Covid-19. One hundred sixty-one infections were identified when participants were unvaccinated; eight were identified among those partially immunized and three were identified among those fully immunized -- more than 14 days after their second dose of vaccine. Thirty-three identified cases were excluded because the person's immune status was not clear.

More than 87% of Covid-19 cases had symptoms. Nearly 23% of the cases sought help from a doctor. There were two hospitalizations, but no deaths.

The results of this study are similar to what scientists saw in clinical trials for the vaccines, but studies like this are important to show how effective the vaccines are, particularly in a population that, through their work, can encounters a large number of people who have Covid-19.

The results showing the level of protection from a single dose after two weeks are similar to findings from other recent studies in the UK and Israel.

'Reducing the risk for transmissible infection, which can occur among persons with asymptomatic infection or among persons several days before symptoms onset, is especially important among health care personnel, first responders, and other essential and frontline workers given their potential to transmit the virus through frequent close contact with patients and the public,' the report concluded.

'This study is tremendously encouraging,' CDC Director Dr. Rochelle Walensky said Monday at the White House Covid-19 briefing. 'These findings also underscore the importance of getting both of the recommended doses of the vaccine in order to get the greatest level of protection against Covid-19, especially as our concerns about variants escalate.'

'Our national vaccination efforts are working,' Walensky added.

The US has made a big push to get people vaccinated. As of Monday, nearly 29% of the US population -- more than 95 million people -- have received at least one dose, and nearly 16% of the population -- about 52.6 million people -- are fully vaccinated, CDC data shows. Among those 18 and older, more than 1 in 5 are fully vaccinated.

'Get vaccinated when you can,' Walensky said. 'So that all those people that we all love will still be here when this pandemic ends.'

Mississippi Coronavirus Cases

Data is updated nightly.

Cases: 515504

Reported Deaths: 10296
CountyCasesDeaths
Harrison34999558
DeSoto33360432
Hinds32743643
Jackson24906392
Rankin22565405
Lee16455245
Madison14954283
Jones14158248
Forrest13834260
Lauderdale12311323
Lowndes11357193
Lamar10693140
Pearl River9748244
Lafayette8868143
Hancock7849132
Washington7559169
Oktibbeha7229138
Monroe7068179
Pontotoc7033110
Warren6885178
Panola6791135
Neshoba6744210
Marshall6707142
Bolivar6468151
Union643598
Pike5942157
Alcorn5921107
Lincoln5540136
George510680
Prentiss508285
Tippah495683
Itawamba4884107
Scott478999
Tate4777117
Adams4776125
Leflore4749144
Copiah458195
Yazoo458092
Simpson4566117
Wayne443472
Covington434895
Sunflower4319106
Marion4295112
Coahoma4244110
Leake414191
Newton396182
Tishomingo386894
Grenada3789109
Stone366166
Jasper341266
Attala340490
Chickasaw318367
Winston318392
Clay312978
Clarke301695
Calhoun286850
Holmes272889
Smith270552
Yalobusha244947
Tallahatchie232353
Greene225149
Walthall222166
Lawrence220242
Perry214556
Amite210357
Webster206548
Noxubee188843
Montgomery182157
Carroll175441
Jefferson Davis174343
Tunica163539
Benton153139
Kemper145441
Choctaw137027
Claiborne134839
Humphreys132239
Franklin126530
Quitman107828
Wilkinson106139
Jefferson97134
Sharkey65321
Issaquena1957
Unassigned00

Alabama Coronavirus Cases

Cases: 848137

Reported Deaths: 16185
CountyCasesDeaths
Jefferson1164052005
Mobile743681384
Madison53497738
Shelby38435371
Baldwin38195589
Tuscaloosa36152644
Montgomery34562782
Lee25655264
Calhoun22630520
Morgan22530411
Etowah20069520
Marshall18846318
Houston17777426
St. Clair16958359
Limestone16195220
Cullman16157306
Elmore15940295
Lauderdale15069307
Talladega14260302
DeKalb13083271
Walker12168380
Blount10779193
Autauga10560157
Jackson10214196
Coffee9435192
Colbert9366210
Dale9044192
Tallapoosa7285202
Russell710065
Chilton7090170
Covington6969197
Escambia6967144
Franklin6364108
Chambers5801142
Marion5437132
Dallas5302210
Pike5129109
Clarke485786
Lawrence4850130
Winston4793110
Geneva4655136
Bibb435795
Barbour370680
Butler3444101
Marengo342993
Monroe338366
Randolph337867
Pickens334890
Fayette331785
Henry321166
Cherokee320364
Hale319189
Crenshaw261678
Washington256852
Cleburne255460
Lamar253555
Clay252969
Macon246367
Conecuh193562
Coosa186048
Wilcox178538
Lowndes178468
Bullock152845
Perry141840
Sumter139841
Greene130545
Choctaw94428
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