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AstraZeneca vaccine is 79% effective against symptomatic Covid-19, company says

AstraZeneca's Covid-19 vaccine showed 79% effi...

Posted: Mar 22, 2021 9:09 AM
Updated: Mar 23, 2021 9:22 AM

AstraZeneca's Covid-19 vaccine showed 79% efficacy against symptomatic disease and 100% efficacy against severe disease and hospitalization in a new, US-based clinical trial, the company said Monday.

The findings from the new Phase 3 trial, which included more than 32,000 participants, may boost confidence in the vaccine, which was originally developed by the University of Oxford.

The trial showed that the vaccine was well-tolerated and identified no safety concerns, the company said. An independent committee "found no increased risk of thrombosis or events characterized by thrombosis among the 21,583 participants receiving at least one dose of the vaccine," according to AstraZeneca.

The new data came from a Phase 3 clinical trial conducted in the US, Chile and Peru. AstraZeneca says it plans to submit the findings to a scientific journal for peer review.

Ruud Dobber, president of AstraZeneca's biopharmaceuticals business unit, said on CNBC Monday that the company plans to apply for emergency use authorization from the US Food and Drug Administration in the first half of April. If authorized, it would be the fourth Covid-19 vaccine available in the United States.

For its part, Oxford said the findings add "to previous trial data from the United Kingdom, Brazil and South Africa, as well as real-world impact data from the United Kingdom" according to a press release from the university.

As part of the trial, more than 32,000 adult volunteers recruited across all ages received either two doses of the vaccine or a placebo vaccine at a four-week interval.

About 79% of trial participants were White, 22% were Hispanic, 8% were Black, 4% were Native American and 4% were Asian.

About 20% of participants were 65 years and over and approximately 60% had conditions linked with higher risk of severe Covid-19, such as diabetes, severe obesity or heart disease.

In patients 65 years and older, vaccine efficacy was 80%, AstraZeneca said -- echoing the overall trial results -- which is notable as some countries initially did not authorize the vaccine for use in this older age group, citing a lack of data from earlier trials.

"It is clear this vaccine has very good efficacy (remember that 60% was, prior to any trials being started, regarded as a good target), and that this efficacy does not show a notable decline at older ages," Stephen Evans, a professor of pharmacoepidemiology at the London School of Hygiene & Tropical Medicine, said in a statement to the Science Media Centre in the UK.

Evans called previous assertions that the vaccine may be ineffective in older ages"totally unjustified."

The Oxford-AstraZeneca vaccine became the subject of controversy earlier in the month when a number of European countries including Norway, France and Denmark decided to temporarily suspend its rollout due to reports of blood clotting in patients post inoculation.

An emergency investigation by the European Medicines Agency (EMA) came to the conclusion last Thursday that the vaccine is "safe and effective" in preventing coronavirus and "not associated with an increase in the overall risk of thromboembolic events, or blood clots."

Lead Investigator for the vaccine and professor of Paediatric Infection and Immunity at Oxford University Andrew Pollard said the AstraZeneca data was "consistent with the results from Oxford-led trials," adding that he expected a "strong impact against COVID-19 across all ages and for people of all different backgrounds from widespread use of the vaccine."

Dr. Peter Hotez, dean for the National School for Tropical Medicine at the Baylor College of Medicine, told CNN's Alisyn Camerota the results were good news for the United States and the world.

"I'm pretty confident now AstraZeneca will apply for, request emergency use authorization, so we'll have that vaccine released to the American public," Hotez said. Covid-19 vaccines by Pfizer/BioNTech, Moderna and Johnson & Johnson have previously been authorized in the United States.

Despite recent pauses in the vaccine's rollout, "this is one of our workhorse vaccines that we're expecting for Africa and Latin America," Hotez said. "So this is good news also because it's reaffirming for the vaccines used for global health as well."

Mississippi Coronavirus Cases

Data is updated nightly.

Cases: 319704

Reported Deaths: 7369
CountyCasesDeaths
DeSoto22276267
Hinds20677421
Harrison18407317
Rankin13880282
Jackson13689248
Madison10249224
Lee10056176
Jones8464167
Forrest7827153
Lauderdale7260242
Lowndes6509150
Lamar634888
Lafayette6310121
Washington5420137
Bolivar4837133
Panola4669110
Oktibbeha466098
Pearl River4604147
Marshall4573105
Warren4440121
Pontotoc425373
Union415777
Monroe4155135
Neshoba4061179
Lincoln4008112
Hancock386687
Leflore3515125
Tate342486
Sunflower339491
Pike3369111
Alcorn325972
Scott320174
Yazoo314171
Adams307486
Itawamba305178
Copiah299966
Coahoma298784
Simpson298189
Tippah291968
Prentiss283861
Leake271974
Marion271280
Covington267283
Wayne264442
Grenada264087
George252051
Newton248663
Tishomingo231568
Winston229981
Jasper222148
Attala215073
Chickasaw210559
Holmes190374
Clay187854
Stone187833
Tallahatchie180041
Clarke178980
Calhoun174132
Yalobusha167840
Smith164034
Walthall135347
Greene131833
Lawrence131024
Montgomery128643
Noxubee128034
Perry127138
Amite126342
Carroll122330
Webster115032
Jefferson Davis108033
Tunica108027
Claiborne103130
Benton102325
Humphreys97533
Kemper96629
Franklin85023
Quitman82216
Choctaw79118
Wilkinson69532
Jefferson66228
Sharkey50917
Issaquena1696
Unassigned00

Alabama Coronavirus Cases

Cases: 548323

Reported Deaths: 11288
CountyCasesDeaths
Jefferson809531565
Mobile42066826
Madison35663525
Tuscaloosa26162458
Shelby25595254
Montgomery25081612
Baldwin21839313
Lee16265176
Calhoun14718325
Morgan14626285
Etowah14171363
Marshall12449230
Houston10764288
Elmore10295213
Limestone10182157
St. Clair10160251
Cullman9941201
Lauderdale9596249
DeKalb8967189
Talladega8458184
Walker7335280
Autauga7230113
Blount6944139
Jackson6922113
Colbert6414140
Coffee5627127
Dale4929114
Russell454941
Chilton4472116
Franklin431083
Covington4273122
Tallapoosa4136155
Escambia401780
Chambers3726124
Dallas3607156
Clarke352961
Marion3242106
Pike314078
Lawrence3129100
Winston283572
Bibb268464
Geneva257581
Marengo250665
Pickens236862
Barbour234659
Hale226878
Butler224071
Fayette218162
Henry193843
Cherokee187245
Randolph187044
Monroe179341
Washington170439
Macon162951
Clay160159
Crenshaw155657
Cleburne153244
Lamar146537
Lowndes142054
Wilcox127030
Bullock124242
Conecuh113430
Coosa111429
Perry108626
Sumter105732
Greene93534
Choctaw62025
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We continue to monitor a tropical disturbance in the Gulf of Mexico. This will be in heavy rainfall two locations across the southeast over the course of the weekend, and flooding rainfall could be in tow as well. Things are looking better for Father’s Day itself, thankfully.
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