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US advisers endorse single-shot COVID-19 vaccine from J&J

U.S. health advisers have endorsed a one-dose COVID-19 vaccine from Johnson & Johnson that's expected to provide an easier-to-use option to fight the pandemic.

Posted: Feb 26, 2021 4:20 PM
Updated: Feb 27, 2021 6:29 PM

WASHINGTON (AP) — U.S. health advisers endorsed a one-dose COVID-19 vaccine from Johnson & Johnson on Friday, putting the nation on the cusp of adding an easier-to-use option to fight the pandemic.

The Food and Drug Administration is expected to quickly follow the recommendation and make J&J’s shot the third vaccine authorized for emergency use in the U.S. Vaccinations are picking up speed, but new supplies are urgently needed to stay ahead of a mutating virus that has killed more than 500,000 Americans.

After daylong discussions, the FDA panelists voted unanimously that the benefits of the vaccine outweighed the risks for adults. If the FDA agrees, shipments of a few million doses could begin as early as Monday.

More than 47 million people in the U.S., or 14% of the population, have received at least one shot of the two-dose vaccines from Pfizer and Moderna, which FDA authorized in December. But the pace of vaccinations has been strained by limited supplies and delays due to winter storms.

While early J&J supplies will be small, the company has said it can deliver 20 million doses by the end of March and a total of 100 million by the end of June.

J&J’s vaccine protects against the worst effects of COVID-19 after one shot, and it can be stored up to three months at refrigerator temperatures, making it easier to handle than the previous vaccines, which must be frozen.

One challenge in rolling out the new vaccine will be explaining how protective the J&J shot is after the astounding success of the first U.S. vaccines.

The two-dose Pfizer and Moderna shots were found to be about 95% effective against symptomatic COVID-19. The numbers from J&J’s study are not that high, but it's not an apples-to-apples comparison. One dose of the J&J vaccine was 85% protective against the most severe COVID-19. After adding in moderate cases, the total effectiveness dropped to about 66%.

Some experts fear that lower number could feed public perceptions that J&J’s shot is a “second-tier vaccine.” But the difference in protection reflects when and where J&J conducted its studies.

J&J’s vaccine was tested in the U.S., Latin America and South Africa at a time when more contagious mutated versions of the virus were spreading. That wasn’t the case last fall, when Pfizer and Moderna were wrapping up testing, and it’s not clear if their numbers would hold against the most worrisome of those variants.

Importantly, the FDA reported this week that, just like its predecessors, the J&J shot offers strong protection against the worst outcomes, hospitalization and death.

While J&J is seeking FDA authorization for its single-dose version, the company is also studying whether a second dose boosts protection.

Panel member Dr. Paul Offit warned that launching a two-dose version of the vaccine down the road might cause problems.

“You can see where that would be confusing to people thinking, ’Maybe I didn’t get what I needed,’” said Offit, a vaccine expert at Children’s Hospital of Philadelphia. “It’s a messaging challenge.”

J&J representatives said they chose to begin with the single shot because the World Health Organization and other experts agreed it would be a faster, more effective tool in an emergency.

Cases and hospitalizations have fallen dramatically since their January peak that followed the winter holidays. But public health officials warned that those gains may be stalling as more variants take root in the U.S.

“We may be done with the virus, but clearly the virus is not done with us,” Centers for Disease Control and Prevention director Dr. Rochelle Walensky, said, speaking at the White House on Friday. She noted that new COVID-19 cases have increased over the past few days.

While it’s too early to tell if the trend will last, Walensky said adding a third vaccine “will help protect more people faster.” More vaccines are in the pipeline.

On Sunday, a CDC panel is expected to meet to recommend how to best prioritize use of the J&J vaccine.

Other parts of the world already are facing which-is-best challenges. Italy’s main teachers’ union recently protested when the government decided to reserve Pfizer and Moderna shots for the elderly and designate AstraZeneca’s vaccine for younger, at-risk workers. AstraZeneca’s vaccine was deemed to be about 70% effective in testing. Canada became the latest country Friday to allow use of AstraZeneca’s vaccine.

Mississippi Coronavirus Cases

Data is updated nightly.

Cases: 500286

Reported Deaths: 9968
CountyCasesDeaths
Harrison34281537
DeSoto32039402
Hinds31911626
Jackson24466379
Rankin21971390
Lee15501235
Madison14566279
Jones13825242
Forrest13438250
Lauderdale11984316
Lowndes11003188
Lamar10510135
Pearl River9494237
Lafayette8542139
Hancock7727126
Washington7418157
Oktibbeha7139131
Monroe6765176
Warren6679176
Pontotoc6655102
Neshoba6625206
Panola6511131
Marshall6460134
Bolivar6302148
Union601294
Pike5815152
Alcorn5662101
Lincoln5431134
George496579
Scott472198
Tippah468381
Prentiss466581
Leflore4654144
Itawamba4628105
Adams4584119
Tate4579109
Copiah447792
Simpson4440116
Yazoo443687
Wayne439172
Covington428694
Sunflower4235105
Marion4225107
Coahoma4154104
Leake408088
Newton381679
Grenada3703108
Stone359764
Tishomingo359492
Attala331089
Jasper329565
Winston314091
Clay307676
Chickasaw299467
Clarke292194
Calhoun278945
Holmes267887
Smith263350
Yalobusha233347
Tallahatchie226851
Walthall218763
Greene218248
Lawrence212440
Perry205256
Amite204755
Webster202646
Noxubee186440
Montgomery179456
Jefferson Davis171442
Carroll168738
Tunica159439
Benton148438
Kemper141941
Choctaw133326
Claiborne132237
Humphreys129238
Franklin119428
Quitman106428
Wilkinson104839
Jefferson94434
Sharkey64020
Issaquena1937
Unassigned00

Alabama Coronavirus Cases

Cases: 815989

Reported Deaths: 15311
CountyCasesDeaths
Jefferson1144621915
Mobile723961330
Madison52114694
Shelby37488348
Baldwin37167547
Tuscaloosa35013606
Montgomery34031734
Lee23177245
Calhoun22190476
Morgan20719376
Etowah19774497
Marshall18277302
Houston17333411
St. Clair15967339
Cullman15365292
Limestone15270198
Elmore15126284
Lauderdale14205294
Talladega13783276
DeKalb12598260
Walker11142369
Blount10132175
Autauga9910146
Jackson9819182
Coffee9190191
Dale8874185
Colbert8803201
Tallapoosa7063198
Escambia6755130
Covington6695184
Chilton6608161
Russell626659
Franklin5947105
Chambers5563142
Marion4966126
Dallas4902200
Clarke474083
Pike4722105
Geneva4567126
Winston4493103
Lawrence4286117
Bibb423686
Barbour356576
Marengo337489
Monroe330863
Randolph328263
Butler325396
Pickens314182
Henry311865
Hale310688
Cherokee301660
Fayette291379
Washington251151
Cleburne247160
Crenshaw244075
Clay241268
Macon231763
Lamar219547
Conecuh185753
Coosa179439
Lowndes174464
Wilcox167839
Bullock151644
Perry138440
Sumter132038
Greene126244
Choctaw87827
Out of AL00
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Tupelo
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Columbus
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Oxford
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Starkville
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More high pressure will move back into our area overnight and into our Friday. This high pressure will bring back into our area some more dry and seasonable weather for a few days.
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