Moderna says its Covid-19 vaccine is safe and appears effective in adolescents

Moderna's Covid-19 vaccine is safe and appears to be effective in adolescents, the company said Tuesday.In a Phase 2/3 trial of 3,732 children ages 12...

Posted: May 25, 2021 1:11 PM

Moderna's Covid-19 vaccine is safe and appears to be effective in adolescents, the company said Tuesday.

In a Phase 2/3 trial of 3,732 children ages 12 to 17 in the United States, blood tests showed that the vaccine produced an immune response that was equivalent to earlier findings in adults.

The trial wasn't designed to look specifically at efficacy. However, initial observations found that none of the children who received the vaccine got sick with Covid-19 starting 14 days after their second dose. Four of the children who received the placebo tested positive for Covid-19, which Moderna says is "consistent with a vaccine efficacy of 100%." The company notes that figure could change as more data is collected.

In the trial, a case was defined as someone who had at least two coronavirus symptoms or one symptom and a positive Covid-19 test.

The company also reviewed how well the vaccine worked after just one dose. The results suggest the vaccine was 93% effective after one dose at preventing mild cases of Covid-19, involving only one symptom of coronavirus disease instead of two or more symptoms.

Moderna announced the results Tuesday in a news release, and the results have not yet been peer reviewed or published.

The company said the vaccine was "generally well tolerated" and that no significant safety concerns were identified. Side effects included headache, fatigue, muscle pain and chills after administration of the second dose. Pain at the injection site was also sometimes observed.

Moderna says it plans to submit the results to the US Food and Drug Administration in early June along with a request for authorization to use the vaccine in adolescents. It also plans to submit the data to a peer-reviewed publication.

The Moderna vaccine is already authorized for use in people ages 18 and older. After Moderna asks the FDA for emergency use authorization of its vaccine for adolescents, the agency will review data submitted by the company, potentially consulting its advisers. If the data is solid, the FDA will give the vaccine the green light for this vaccine to be used in younger people.

The FDA has already expanded the emergency use authorization for Pfizer/BioNTech's Covid-19 vaccine to include people ages 12 to 15 earlier this month. The vaccine had previously been authorized for people ages 16 and older.

Because these vaccines have been used safely in adults, vaccine experts said that was a relatively easy process. The Pfizer decision was made without a meeting of the FDA's independent Vaccines and Related Biological Products Advisory Committee. The US Centers for Disease Control and Prevention's Advisory Committee on Immunization Practices met a few days later to recommend use Pfizer's vaccines in adolescents.

Both Pfizer and Moderna are currently testing their vaccines in younger children, ages 6 months to 11 years. Because those age groups may require varying doses, the process will likely take a little longer.

Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, recently said elementary age children likely won't be vaccinated until the end of the year.

Mississippi Coronavirus Cases

Data is updated nightly.

Cases: 482902

Reported Deaths: 9425
CountyCasesDeaths
Harrison33063488
Hinds31021589
DeSoto30610358
Jackson23687348
Rankin21340370
Lee14909220
Madison14166271
Jones13404227
Forrest13160240
Lauderdale11601305
Lowndes10443176
Lamar10214130
Pearl River9098221
Lafayette8241137
Hancock7514112
Washington7102150
Oktibbeha6964124
Monroe6514164
Neshoba6475201
Warren6464164
Pontotoc630393
Panola6250126
Marshall6126123
Bolivar6115144
Union574186
Pike5613136
Alcorn537290
Lincoln5303131
George471472
Scott459196
Leflore4476140
Prentiss446779
Tippah446480
Itawamba4444100
Adams4416116
Tate4394101
Simpson4335112
Wayne433066
Copiah431787
Yazoo423386
Covington415792
Sunflower4148104
Marion4099104
Leake397586
Coahoma3957100
Newton370875
Grenada3556104
Stone350860
Tishomingo336289
Attala325387
Jasper314162
Winston304691
Clay296473
Chickasaw287065
Clarke282190
Calhoun266141
Holmes262187
Smith250649
Yalobusha221047
Tallahatchie220450
Walthall211058
Greene209045
Lawrence206833
Perry199953
Amite198452
Webster196542
Noxubee178939
Montgomery172454
Jefferson Davis168342
Carroll162137
Tunica153334
Benton142535
Kemper138640
Choctaw127026
Claiborne126834
Humphreys126637
Franklin116728
Quitman103926
Wilkinson101936
Jefferson91333
Sharkey63020
Issaquena1926
Unassigned00

Alabama Coronavirus Cases

Cases: 784484

Reported Deaths: 13921
CountyCasesDeaths
Jefferson1111691760
Mobile707171225
Madison49549625
Baldwin36108489
Shelby36062314
Tuscaloosa33661547
Montgomery33066676
Lee22407219
Calhoun21041405
Morgan19734334
Etowah19001459
Marshall17619274
Houston16697382
St. Clair15361303
Cullman14506257
Limestone14505187
Elmore14387260
Lauderdale13436280
Talladega12855234
DeKalb12140236
Walker10524329
Blount9649156
Autauga9642137
Jackson9325156
Coffee8793175
Dale8529172
Colbert8482182
Tallapoosa6616177
Escambia6553120
Covington6420165
Chilton6342143
Russell602455
Franklin5758101
Chambers5370133
Marion4769117
Dallas4676187
Pike460096
Clarke459878
Geneva4371116
Winston422994
Lawrence4107108
Bibb407380
Barbour343270
Marengo325683
Monroe317152
Butler316490
Randolph304456
Pickens301873
Henry300357
Hale291584
Cherokee288353
Fayette277973
Washington245148
Crenshaw237069
Cleburne231150
Clay226765
Macon218658
Lamar193342
Conecuh181346
Lowndes170758
Coosa168033
Wilcox159736
Bullock148842
Perry136336
Sumter124336
Greene120642
Choctaw73326
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While some cool mornings are again in store for the weekend, afternoons start to warm up a bit, so plan on dressing in layers if you're heading to the MSU or Bama games, because you'll need to utilize them in different ways.
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