CDC reports most J&J vaccine side effects are 'nonserious,' 17 cases of blood clot condition

A new review of Johnson & Johnson Covid-19 vaccine safety moni...

Posted: Apr 30, 2021 5:02 PM

A new review of Johnson & Johnson Covid-19 vaccine safety monitoring data finds that only 3% of reported reactions after receiving the vaccine are classified as serious -- and there have been a total of 17 incidents of severe blood clotting while also experiencing low blood platelet levels.

The report, published on Friday by the US Centers for Disease Control and Prevention, notes that the safety profile of the vaccine so far has been similar to what was seen in clinical trials, but safety monitoring during the vaccine's rollout quickly identified the blood clot incidents.

"A rare but serious adverse event occurring primarily in women, blood clots in large vessels accompanied by a low platelet count, was rapidly detected by the U.S. vaccine safety monitoring system," CDC researchers wrote in the report. "Monitoring for common and rare adverse events after receipt of all COVID-19 vaccines, including the Janssen COVID-19 vaccine, is continuing."

Janssen is the vaccine arm of Johnson & Johnson. In February, the Johnson & Johnson vaccine was authorized for emergency use in the United States. Use of the vaccine was paused temporarily in mid-April due to reports of extremely rare yet severe blood clotting events in the brain's venous sinuses following vaccinations. The pause lifted last week.

The new CDC report summarizes the latest safety data on the vaccine, which includes 13,725 incidents reported through the agency's Vaccine Adverse Events Reporting System. The data showed that 97% of the events have been nonserious.

Overall, there were 17 events consistent with what has been described as thrombosis with thrombocytopenia syndrome, or blood clotting with low blood platelet levels -- including 14 that were cerebral venous sinus thrombosis and three that did not involve the brain's venous sinuses among women younger than 60 during the vaccine pause, according to the report.

The data also included 88 deaths reported after vaccination. Among those deaths, three occurred in patients with cerebral venous sinus thrombosis and CDC researchers wrote that, after preliminary reviews, "no other deaths appear to have an association with vaccination."

Increased number of 'anxiety-related events'

Additional new data published Friday from the CDC suggests that administration of Johnson & Johnson's Covid-19 vaccine in early April may have also been connected to an increased incidence of "anxiety-related events" in the 15-minute waiting period post-vaccine.

All of these anxiety-related events occurred before reports came out of thrombosis with thrombocytopenia syndrome connected to the Janssen vaccine.

In a study published Friday in the CDC's Morbidity and Mortality Weekly Report, researchers examined data from five mass vaccination sites which reported increased anxiety-related events, including rapid heart rate, rapid breathing, and fainting, following administration of Johnson & Johnson's Janssen Covid-19 vaccine from April 7-9.

Researchers tallied 64 anxiety-related events out of 8,624 vaccine recipients. The rate of syncope, or fainting, was found to be 8.2 incidences per 100,000 doses, which is 164 times the rate of fainting following the flu vaccine, the researchers wrote.

All of the events were reported to Vaccine Adverse Event Reporting System, and none were considered "serious" by VAERS standards. Over half of the reported fainting events occurred in women. For four out of the five sites observed, these events happened on the first day of Janssen shot administration.

Study authors suggested that because the Janssen Covid-19 vaccine is a single-dose shot, people with a fear of needles may be more inclined to get this shot over one of the two-dose options. Out of all fainting cases, 20% of those reported occurred in people who had already informed vaccination site staff they had a history of needle aversion.

Half of the reports of fainting occurred in people ages 18 to 29, and fainting associated with injections is more common in adolescents and young adults. Researchers cited similar fainting rates in administration of the human papillomavirus vaccine, largely given to young people. The HPV vaccine has a fainting rate of 7.8 per 100,000.

Researchers said tracking anxiety event rates will be important information for health care providers as the Covid-19 vaccine reaches more and more young people.

"Anxiety-related events can occur after any vaccination," study authors wrote.

"It is important that vaccination providers are aware that anxiety-related adverse events might be reported more frequently after receipt of the Janssen COVID-19 vaccine than after influenza vaccination and observe all COVID-19 vaccine recipients for any adverse reactions for at least 15 minutes after vaccine administration," the researchers wrote. "As use of COVID-19 vaccines expands into younger age groups, providers should be aware that younger persons might be more highly predisposed to anxiety-related events after vaccination than are older persons."

Mississippi Coronavirus Cases

Data is updated nightly.

Cases: 482902

Reported Deaths: 9425
CountyCasesDeaths
Harrison33063488
Hinds31021589
DeSoto30610358
Jackson23687348
Rankin21340370
Lee14909220
Madison14166271
Jones13404227
Forrest13160240
Lauderdale11601305
Lowndes10443176
Lamar10214130
Pearl River9098221
Lafayette8241137
Hancock7514112
Washington7102150
Oktibbeha6964124
Monroe6514164
Neshoba6475201
Warren6464164
Pontotoc630393
Panola6250126
Marshall6126123
Bolivar6115144
Union574186
Pike5613136
Alcorn537290
Lincoln5303131
George471472
Scott459196
Leflore4476140
Prentiss446779
Tippah446480
Itawamba4444100
Adams4416116
Tate4394101
Simpson4335112
Wayne433066
Copiah431787
Yazoo423386
Covington415792
Sunflower4148104
Marion4099104
Leake397586
Coahoma3957100
Newton370875
Grenada3556104
Stone350860
Tishomingo336289
Attala325387
Jasper314162
Winston304691
Clay296473
Chickasaw287065
Clarke282190
Calhoun266141
Holmes262187
Smith250649
Yalobusha221047
Tallahatchie220450
Walthall211058
Greene209045
Lawrence206833
Perry199953
Amite198452
Webster196542
Noxubee178939
Montgomery172454
Jefferson Davis168342
Carroll162137
Tunica153334
Benton142535
Kemper138640
Choctaw127026
Claiborne126834
Humphreys126637
Franklin116728
Quitman103926
Wilkinson101936
Jefferson91333
Sharkey63020
Issaquena1926
Unassigned00

Alabama Coronavirus Cases

Cases: 784484

Reported Deaths: 13921
CountyCasesDeaths
Jefferson1111691760
Mobile707171225
Madison49549625
Baldwin36108489
Shelby36062314
Tuscaloosa33661547
Montgomery33066676
Lee22407219
Calhoun21041405
Morgan19734334
Etowah19001459
Marshall17619274
Houston16697382
St. Clair15361303
Cullman14506257
Limestone14505187
Elmore14387260
Lauderdale13436280
Talladega12855234
DeKalb12140236
Walker10524329
Blount9649156
Autauga9642137
Jackson9325156
Coffee8793175
Dale8529172
Colbert8482182
Tallapoosa6616177
Escambia6553120
Covington6420165
Chilton6342143
Russell602455
Franklin5758101
Chambers5370133
Marion4769117
Dallas4676187
Pike460096
Clarke459878
Geneva4371116
Winston422994
Lawrence4107108
Bibb407380
Barbour343270
Marengo325683
Monroe317152
Butler316490
Randolph304456
Pickens301873
Henry300357
Hale291584
Cherokee288353
Fayette277973
Washington245148
Crenshaw237069
Cleburne231150
Clay226765
Macon218658
Lamar193342
Conecuh181346
Lowndes170758
Coosa168033
Wilcox159736
Bullock148842
Perry136336
Sumter124336
Greene120642
Choctaw73326
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While some cool mornings are again in store for the weekend, afternoons start to warm up a bit, so plan on dressing in layers if you're heading to the MSU or Bama games, because you'll need to utilize them in different ways.
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