AstraZeneca vaccine is 79% effective against symptomatic Covid-19, company says

AstraZeneca's Covid-19 vaccine showed 79% effi...

Posted: Mar 22, 2021 9:09 AM
Updated: Mar 23, 2021 9:22 AM

AstraZeneca's Covid-19 vaccine showed 79% efficacy against symptomatic disease and 100% efficacy against severe disease and hospitalization in a new, US-based clinical trial, the company said Monday.

The findings from the new Phase 3 trial, which included more than 32,000 participants, may boost confidence in the vaccine, which was originally developed by the University of Oxford.

The trial showed that the vaccine was well-tolerated and identified no safety concerns, the company said. An independent committee "found no increased risk of thrombosis or events characterized by thrombosis among the 21,583 participants receiving at least one dose of the vaccine," according to AstraZeneca.

The new data came from a Phase 3 clinical trial conducted in the US, Chile and Peru. AstraZeneca says it plans to submit the findings to a scientific journal for peer review.

Ruud Dobber, president of AstraZeneca's biopharmaceuticals business unit, said on CNBC Monday that the company plans to apply for emergency use authorization from the US Food and Drug Administration in the first half of April. If authorized, it would be the fourth Covid-19 vaccine available in the United States.

For its part, Oxford said the findings add "to previous trial data from the United Kingdom, Brazil and South Africa, as well as real-world impact data from the United Kingdom" according to a press release from the university.

As part of the trial, more than 32,000 adult volunteers recruited across all ages received either two doses of the vaccine or a placebo vaccine at a four-week interval.

About 79% of trial participants were White, 22% were Hispanic, 8% were Black, 4% were Native American and 4% were Asian.

About 20% of participants were 65 years and over and approximately 60% had conditions linked with higher risk of severe Covid-19, such as diabetes, severe obesity or heart disease.

In patients 65 years and older, vaccine efficacy was 80%, AstraZeneca said -- echoing the overall trial results -- which is notable as some countries initially did not authorize the vaccine for use in this older age group, citing a lack of data from earlier trials.

"It is clear this vaccine has very good efficacy (remember that 60% was, prior to any trials being started, regarded as a good target), and that this efficacy does not show a notable decline at older ages," Stephen Evans, a professor of pharmacoepidemiology at the London School of Hygiene & Tropical Medicine, said in a statement to the Science Media Centre in the UK.

Evans called previous assertions that the vaccine may be ineffective in older ages"totally unjustified."

The Oxford-AstraZeneca vaccine became the subject of controversy earlier in the month when a number of European countries including Norway, France and Denmark decided to temporarily suspend its rollout due to reports of blood clotting in patients post inoculation.

An emergency investigation by the European Medicines Agency (EMA) came to the conclusion last Thursday that the vaccine is "safe and effective" in preventing coronavirus and "not associated with an increase in the overall risk of thromboembolic events, or blood clots."

Lead Investigator for the vaccine and professor of Paediatric Infection and Immunity at Oxford University Andrew Pollard said the AstraZeneca data was "consistent with the results from Oxford-led trials," adding that he expected a "strong impact against COVID-19 across all ages and for people of all different backgrounds from widespread use of the vaccine."

Dr. Peter Hotez, dean for the National School for Tropical Medicine at the Baylor College of Medicine, told CNN's Alisyn Camerota the results were good news for the United States and the world.

"I'm pretty confident now AstraZeneca will apply for, request emergency use authorization, so we'll have that vaccine released to the American public," Hotez said. Covid-19 vaccines by Pfizer/BioNTech, Moderna and Johnson & Johnson have previously been authorized in the United States.

Despite recent pauses in the vaccine's rollout, "this is one of our workhorse vaccines that we're expecting for Africa and Latin America," Hotez said. "So this is good news also because it's reaffirming for the vaccines used for global health as well."

Mississippi Coronavirus Cases

Data is updated nightly.

Cases: 482902

Reported Deaths: 9425
CountyCasesDeaths
Harrison33063488
Hinds31021589
DeSoto30610358
Jackson23687348
Rankin21340370
Lee14909220
Madison14166271
Jones13404227
Forrest13160240
Lauderdale11601305
Lowndes10443176
Lamar10214130
Pearl River9098221
Lafayette8241137
Hancock7514112
Washington7102150
Oktibbeha6964124
Monroe6514164
Neshoba6475201
Warren6464164
Pontotoc630393
Panola6250126
Marshall6126123
Bolivar6115144
Union574186
Pike5613136
Alcorn537290
Lincoln5303131
George471472
Scott459196
Leflore4476140
Prentiss446779
Tippah446480
Itawamba4444100
Adams4416116
Tate4394101
Simpson4335112
Wayne433066
Copiah431787
Yazoo423386
Covington415792
Sunflower4148104
Marion4099104
Leake397586
Coahoma3957100
Newton370875
Grenada3556104
Stone350860
Tishomingo336289
Attala325387
Jasper314162
Winston304691
Clay296473
Chickasaw287065
Clarke282190
Calhoun266141
Holmes262187
Smith250649
Yalobusha221047
Tallahatchie220450
Walthall211058
Greene209045
Lawrence206833
Perry199953
Amite198452
Webster196542
Noxubee178939
Montgomery172454
Jefferson Davis168342
Carroll162137
Tunica153334
Benton142535
Kemper138640
Choctaw127026
Claiborne126834
Humphreys126637
Franklin116728
Quitman103926
Wilkinson101936
Jefferson91333
Sharkey63020
Issaquena1926
Unassigned00

Alabama Coronavirus Cases

Cases: 784484

Reported Deaths: 13921
CountyCasesDeaths
Jefferson1111691760
Mobile707171225
Madison49549625
Baldwin36108489
Shelby36062314
Tuscaloosa33661547
Montgomery33066676
Lee22407219
Calhoun21041405
Morgan19734334
Etowah19001459
Marshall17619274
Houston16697382
St. Clair15361303
Cullman14506257
Limestone14505187
Elmore14387260
Lauderdale13436280
Talladega12855234
DeKalb12140236
Walker10524329
Blount9649156
Autauga9642137
Jackson9325156
Coffee8793175
Dale8529172
Colbert8482182
Tallapoosa6616177
Escambia6553120
Covington6420165
Chilton6342143
Russell602455
Franklin5758101
Chambers5370133
Marion4769117
Dallas4676187
Pike460096
Clarke459878
Geneva4371116
Winston422994
Lawrence4107108
Bibb407380
Barbour343270
Marengo325683
Monroe317152
Butler316490
Randolph304456
Pickens301873
Henry300357
Hale291584
Cherokee288353
Fayette277973
Washington245148
Crenshaw237069
Cleburne231150
Clay226765
Macon218658
Lamar193342
Conecuh181346
Lowndes170758
Coosa168033
Wilcox159736
Bullock148842
Perry136336
Sumter124336
Greene120642
Choctaw73326
Out of AL00
Unassigned00
Tupelo
Clear
57° wxIcon
Hi: 83° Lo: 51°
Feels Like: 57°
Columbus
Clear
54° wxIcon
Hi: 82° Lo: 50°
Feels Like: 54°
Oxford
Clear
52° wxIcon
Hi: 80° Lo: 48°
Feels Like: 52°
Starkville
Clear
52° wxIcon
Hi: 82° Lo: 51°
Feels Like: 52°
While some cool mornings are again in store for the weekend, afternoons start to warm up a bit, so plan on dressing in layers if you're heading to the MSU or Bama games, because you'll need to utilize them in different ways.
WTVA Radar
WTVA Temperatures
WTVA Severe Weather